3,5- (un) substituted-1H-pyrrolo 2,3-b pyridine, 1H-pyrazolo 3,4-b pyridine, and 5H-pyrrolo 2,3-b pyrazine, ITK and JAK3 kinase Inhibitors of

摘要

The present invention relates to compounds described by formula I, their salts, their synthesis, their use as ITK and JAK3 inhibitors comprising such compounds, and autoimmune diseases, inflammation, joints Of these compounds in the treatment of various diseases and disorders related to abnormal cell proliferation such as rheumatism, systemic lupus erythematosus, atherosclerosis, ulcerative colitis, psoriatic arthritis, psoriasis, Crohn's disease, metabolic and cancer diseases Regarding usage. The present invention further provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions, and methods for preparing the compounds of the invention. [Selection figure] None