2,2-Difluoropropionamide derivatives of bardoxolone methyl, their polymorphs and methods of use

摘要

The present invention generally relates to the compound: N-((4aS, 6aR, 6bS, 8aR, 12aS, 14aR, 14bS) -11-cyano-2,2,6a, 6b, 9,9,12a-heptamethyl-10,14 -Dioxo-1,2,3,4,4a, 5,6,6a, 6b, 7,8,8a, 9,10,12a, 14,14a, 14b-octadecahydropicen-4a-yl) -2 , 2-difluoropropanamide, polymorphs thereof, methods for their preparation and use, pharmaceutical compositions thereof, and kits and products thereof.