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2,2-Difluoropropionamide derivatives of bardoxolone methyl, polymorphs and methods of use
2,2-Difluoropropionamide derivatives of bardoxolone methyl, polymorphs and methods of use
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机译:巴多索隆甲基的2,2-二氟丙酰胺衍生物,多晶型物和使用方法
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摘要
The present invention relates to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-l,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide and polymorphic forms and pharmaceutical compositions thereof for use in the treatment of cancer in combination with immunotherapy, for use in the treatment of conditions associated with oxidative stree caused by mitochondrial dysfunction and for use in the treatment of seizure disorders.
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