Polysialic acid, expression of blood group antigens and glycoproteins

摘要

The present invention described The present specification relates generally to a sugar chain engineering of host cells to produce glycoproteins for use in therapy. Host cells are modified to express the biosynthetic pathway of glycosylation. New prokaryotic host cell is engineered manufactured to produce N- linked glycoproteins containing polysialic acid or blood group antigens.