Sustained release lipid initial formulations and pharmaceutical compositions comprising them cationic pharmacologically active substance

摘要

to provide a pharmaceutical composition comprising sustained-release lipid initial formulation of cationic pharmacologically active substance and this. present invention includes a) a liquid crystal forming agent, b) a neutral phospholipid and (neutral phospholipid), c) a liquid crystal curing agent, d) an anionic fixing agent (anionic anchoring agent), and, to provide a sustained-release lipid initial formulation to form a liquid crystal on the present and the aqueous fluid as lipid liquid phase in the absence of aqueous fluid (pre-concentrate). Slow release lipid initial formulations of the present invention exhibit a function and effect that it is possible to enhance the sustained release of cationic pharmacologically active substances anionic fixing agent and through ionic bonds between the cationic pharmacologically active substance .FIELD 3