Dynamically confining field effect neurite outgrowth for a configurable neural network

摘要

Systems and methods for changing the growth by the frame neurites have been described generally. In some embodiments, the system neurons, including neurite, and may have an electrode capable of producing a physical guidance cue. It said physical guidance cue, the neurite outgrowth can be used to alter, and growth is temporally and / or spatially As may vary temporally and spatially varying neurite it may be. Dynamic control of neurites, binding of directivity of the nerve, crossing, and / or overlap may be used to configure. The system accommodates the living cells, and a chamber capable of promoting the growth of cells, and connected to the chamber, and the channel having about 20 m or less in height and / or width, and, It intersects with the channel, and the spacing between the centers of the electrode has at least one electrode pair is about 200 m or less. A plurality of electrode pairs crossing the channel.