Reduce patient-to-patient variability of levodopa plasma concentrations

摘要

The present invention provides a method of reducing patient-to-patient variability of levodopa plasma concentrations in a population of Parkinson's disease patients. The methods of the present invention may be used at therapeutically effective concentrations such that patient-to-patient variation in levodopa plasma concentrations over a time period ranging from about 10 minutes after inhalation to about 60 minutes or more after inhalation has a coefficient of variation of less than 50%. Including pulmonary administration of levodopa. The methods of the present invention are particularly useful for the treatment of motor symptom fluctuations that occur as a side effect of L-dopa therapy. [Selection] Figure 1