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Inflammatory site integrated compound, nuclear medicine diagnostic imaging agents and labeled precursors

机译:炎症部位整合化合物,核医学诊断显像剂和标记前体

摘要

Embodiments of the invention provide a compound accumulating in an inflammatory site, a diagnostic agent containing the compound in labeled state and its precursor compound for labeling. Such a compound accumulating in inflammatory site may be represented by the following formula (1): Z—Y-Leu-Phe-(X)n-DLys(-(DLys)m-HalB)-(DLys)k-NH2  (1) wherein in the formula (1), Z represents a protective group for an amino group; Y represents Met or Nle; X represents a spacer consisting of one or more of amino acid and/or synthetic organic compounds; n represents 1 or 0; m represents 1 or 0; k represents 1 or 0; and HalB represents a substituted benzoic acid having a radioactive halogen in an aromatic ring.
机译:本发明的实施方案提供了在炎性部位积聚的化合物,含有标记状态的化合物的诊断剂及其用于标记的前体化合物。这种在炎性部位积聚的化合物可以由下式(1)表示:Z-Y-Leu-Phe-(X)n-DLys(-(DLys)m-HalB)-(DLys)k-NH2&emsp ;(1)其中,在式(1)中,Z表示氨基的保护基; Y代表Met或Nle; X代表由一种或多种氨基酸和/或合成有机化合物组成的间隔基; n代表1或0; m表示1或0; k代表1或0; HalB表示在芳香环中具有放射性卤素的取代的苯甲酸。

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