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Small molecules that modulate MCL-1 and methods for modulating cell death, cell division, cell differentiation, and methods of treating diseases.
Small molecules that modulate MCL-1 and methods for modulating cell death, cell division, cell differentiation, and methods of treating diseases.
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机译:调节MCL-1的小分子以及调节细胞死亡,细胞分裂,细胞分化的方法以及治疗疾病的方法。
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摘要
This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.
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