Identification of genetic mutations in the affected tissue

摘要

The manner which decides system unique genetic variation is offered. For example, with feature of specification, the manner which is used for the cellular type of specification of iPS cell origin for differential numerator analysis of system unique genetic variation is stated. With 1st execution configuration, being the manner which decides the existence of the system unique genetic variation in the test subject for the gene structure of the control which is chosen, (a) being the step which obtains the heredity material of the differentiation cell of the system which is chosen, this differentiation cell, it is something which is prepared the artificial multipurpose Characteristic main stem which can by ripuroguramingu of the body cell of the test subject (iPS) by the differentiation of the cell, step and, (b) inspecting the heredity material of the differentiation cell, the gene structure of one or more of the heredity material the control gene structure of one or moreIt compares, the step which decides the existence of this kind of genetic variation because of this in the cell of system of the test subject and, the manner which is included is offered.