The present invention discloses a vacuum pumping device, a vacuum glass manufacturing system and a related method for manufacturing a vacuum glazing. The vacuum pumping device includes: a circular tubular pumping operation unit; a cylindrical pump-out hole sealing operation unit; a control part; and a driving device. The pumping operation unit and the pump-out hole sealing operation unit share a same central axis along which both of the units can be moved relatively, and form a cylinder with the former being outside and the latter being inside. A pumping channel is formed in a tube wall of the pumping operation unit, and a heating unit is disposed in the top portion inside the pump-out hole sealing operation unit. The control part, through the driving device, time-sequentially controls the pumping operation unit and the pump-out hole sealing operation unit to move relatively along the central axis, controls the pumping channel to perform a pre-pumping/pre-pressing operation or a vacuum pumping operation, and controls the heating unit to heat a sealing sheet to perform a pump-out hole sealing operation.
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