Surface-modified iron oxide particles for cancer ablation treatment

摘要

An object of the present invention is to provide surface-modified ferromagnetic iron oxide particles suitable for electromagnetic induction cancer ablation treatment having excellent heat generation characteristics and excellent dispersion stability with respect to an injection medium. The surface-modified iron oxide particles for cancer ablation treatment of the present invention as a solution thereof have a plate-like shape having a major axis of 20 to 200 nm and a major axis to thickness ratio of 1.5 to 30, and a coercive force of 30. ˜300 Oe, saturation magnetization 20˜80 emu / g, magnetic hysteresis curve squareness ratio 0.20˜0.50 on the surface of ferromagnetic iron oxide particles having magnetic properties, polyethylene glycol and phosphorus on the side chain A polystyrene block copolymer having an acid group is bonded thereto.