B5R gene-deficient recombinant vaccinia virus incorporating a hemagglutinin protein gene derived from a new influenza virus

摘要

PROBLEM TO BE SOLVED: To provide a recombinant vaccinia virus effective in blocking the onset of diseases caused by the infection of a new type influenza virus (especially, pandemic influenza virus belonging to H1 subtype) and the preventing and treating medicine, etc., of the new type influenza virus including the recombinant vaccinia virus.SOLUTION: A recombinant vaccinia virus is provided by recombining a B5R protein gene region of the vaccinia virus with an expression promotor and the whole or a part of a cDNA encoding a hemagglutinin protein originated from a pandemic influenza virus belonging to H1 subtype.