Filaggrin production promoter, therapeutic agent for diseases associated with decreased filaggrin production, and screening method for the therapeutic agent

摘要

The present invention provides a substance having a highly effective filaggrin production promoting action. Furthermore, the present invention provides a therapeutic agent useful for the treatment of skin diseases associated with a decrease in filaggrin production, particularly atopic dermatitis. As a result of diligent search for filaggrin production promoters, A) N-quinolylbenzamide derivative (compound 1), B) ivermectin (compound 2) or C) phenylalanine amide derivative (compound 3) produced filaggrin production in the skin. It was found that the water retention ability and barrier function of the stratum corneum were improved satisfactorily. The present invention relates to a filaggrin production promoter characterized by containing a specific N-quinolylbenzamide derivative or a pharmaceutically acceptable salt thereof as an active ingredient.