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Method for evaluating the effects of chemical substances on the living body

机译:评价化学物质对生物体影响的方法

摘要

PROBLEM TO BE SOLVED: To settle the problems that neurotoxicity is hard to precisely comprehend for the sensory abnormality of an experimental animal and, as often accompanying no morphological change, is difficult in evaluation.SOLUTION: Since in vivo changes in gene expressions due to changes in external environments are acute, the identification of a gene set for determining biotoxicity makes it possible to quickly and precisely detect biotoxicity before the biotoxicity takes place and before it is verified by a pathological examination. A method of detecting and predicting biotoxicity by using the new gene set, its kit, a method of treating biotoxicity, and a method of confirming candidate drugs for biotoxicity are provided.
机译:解决的问题:解决神经毒性难以准确理解实验动物的感觉异常的问题,并且通常不伴有形态学变化,因此难以评估。解决方案:由于体内基因表达由于变化而发生变化在外部环境是急性的情况下,鉴定用于确定生物毒性的基因组使得可以在发生生物毒性之前和通过病理学检查证实之前快速而精确地检测生物毒性。提供了一种通过使用新基因组检测和预测生物毒性的方法,其试剂盒,治疗生物毒性的方法以及确定候选药物的生物毒性的方法。

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