PET radiopharmaceuticals for the differential diagnosis of a bilateral state and unilateral state of primary hyperaldosteronism

摘要

A step of introducing to a mammal having adrenal, selectively binds to CYP11B2 (aldosterone synthase) than (1) CYP11B1 (11β- hydroxylase) and CYP11B2 (aldosterone synthase) inhibitors radiolabeled ( including the step of performing positron emission tomography (PET) in the adrenal region in order to obtain functional PET images of 2) adrenal gland, the functional PET imaging methods for differential with unilateral adenoma and bilateral hyperplasia disclose. Furthermore, the radioactive tracer compounds suitable for use in this method, the precursor for making it, performed by one-pot reaction and rapid is also disclosed a method for manufacturing a can the radiotracer compound.