PROBLEM TO BE SOLVED: To provide a production method in which, when producing a solid preparation, particularly a tablet, blended with bisacodyl and dioctyl sodium sulfosuccinate, a yield as the whole of the solid preparation is secured, and reduction in the content of the dioctyl sodium sulfosuccinate is prevented.SOLUTION: The method for producing a bisacodyl and dioctyl sodium sulfosuccinate-blended solid preparation is characterized in that the dioctyl sodium sulfosuccinate is dissolved into a solvent to prepare a 15-45 mass% dioctyl sodium sulfosuccinate solution, with the solution as a granulation solvent, it is added to powder blended with bisacodyl of 0.3 pt.mass to 1 pt.mass of the dioctyl sodium sulfosuccinate in a ratio of ≥700 g per min per kg of the powder, and stirring and granulation are performed.
展开▼
机译：解决的问题：提供一种生产方法，其中当生产固体制剂，特别是片剂时，与比沙可啶和磺基琥珀酸二辛酯钠混合，可确保整个固体制剂的收率，并降低其含量。防止：磺基琥珀酸二辛酯钠溶液的制备方法：特征在于将磺基琥珀酸二辛酯基酯和二辛基磺基琥珀酸二钠酯混合的固体制剂的制备方法是将磺基琥珀酸二辛酯钠溶解在溶剂中制备15-45质量％的磺基琥珀酸二辛酯钠溶液作为造粒溶剂的溶液，以≥700g / min / kg的粉末的比例，添加到与0.3 pts质量比为1 pts磺基琥珀酸二辛酯的比沙可啶混合的粉末中，进行搅拌和制粒。 。
展开▼
