High-order sequence kernel methods for peptide analysis

摘要

System and methods are disclosed to perform peptide-MHC interaction prediction by applying a high-order kernel function to determine a similarity between peptide sequences; applying one or more supervised strategies to the kernel to encode relevant physicochemical and interaction information about peptide sequence and MHC molecule; and applying a classifier to the kernel to identify the peptide-MHC interaction of interest in response to a query.