METHODS OF NORMALIZING THE RATIO OF MEASURED PARENT AND METABOLITE DRUG CONCENTRATIONS IN FLUIDS AND TESTING FOR NON-COMPLIANCE

摘要

Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In an embodiment, the method comprises measuring a drug and a metabolite level in fluid of a subject and transforming the ratio of the measured drug levels and comparing the subsequent Drug Ratio with a likewise transformed Data Set of drug/metabolite ratios. Using the transformed ratio of parent drug to metabolite eliminates the need for further adjustments using patient specific parameters and other transforming/normalizing quantities.