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Two-Dimensional Semi-LASER Correlation Spectroscopy with Well-Maintained Cross Peaks
Two-Dimensional Semi-LASER Correlation Spectroscopy with Well-Maintained Cross Peaks
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机译:具有良好交叉峰的二维半激光相关光谱
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摘要
A sLASER-first-COSY sequence is disclosed. After a delay time, Δ1, from application of a first 90° radio frequency (RF) pulse, a first pair of adiabatic full-passage (AFP) pulses are applied to an object in a MRI scanner. The first 90° RF pulse is a non-adiabatic slice-selective 90° RF pulse and the first pair of AFP pulses is separated by an inter-pulse time interval, Δ2. A second pair of AFP pulses, separated by the time Δ2, is then applied, followed by a second 90° RF pulse. The second 90° RF pulse is a non-adiabatic non-slice-selective 90° RF pulse. MR signal is acquired after an echo time (TE) from application of the excitation RF pulse. The present method may achieve intended full magnetization transfer between a coupled spin pair of a metabolite and maintain metabolite cross peak intensity of a coupled spin pair of a metabolite in the object.
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