METHODS AND PRODUCTS FOR THE DIAGNOSIS AND PROGNOSIS OF OVARIAN TUMOR MALIGNANCY

摘要

The present invention relates to methods and products for the diagnosis and prognosis of ovarian tumor malignancy based on proCOL11A1 protein which is expressed in malignant ovarian tumors but not in non-tumoral ovarian tissue or in situ or benign or borderline ovarian tumors. proCOL11A1-specific antibodies can be used for high sensitivity and specificity diagnosis of ovarian cancer as well as for differentiating malignant ovarian tumors from benign or in situ tumors, and for the prognosis of ovarian tumor malignancy and for predicting borderline tumor malignancy. The invention has application in in vitro methods for the diagnosis and prognosis of ovarian tumor malignancy.