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GENETIC TESTING FOR IMPROVED CATTLE FERTILITY
GENETIC TESTING FOR IMPROVED CATTLE FERTILITY
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机译:遗传测试,提高牛的繁殖力
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摘要
Arrays of nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods based on novel SNPs on genes of the bovine transforming growth factor-β (TGF-β) signaling pathway for improved bovine fertilization rate. The methods and compositions of the present invention are related to SNPs in the DNA-binding protein inhibitor 3 (ID3) gene, and in the bone morphogenetic protein 4 (BMP4) gene corresponding to position 2702 of SEQ ID NO: 2. Also disclosed are methods for determining viability of developing bovine embryos by measuring the expression level of one or more target genes in the TGF-signaling pathway, and selecting for implantation only embryos whose target gene expression level is not up-regulated.
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机译:基于新型SNP的核酸分子阵列,试剂盒,基因分型方法和标记辅助的牛育种方法,基于牛转化生长因子-β(TGF-β)信号传导途径的基因,可提高牛的受精率。本发明的方法和组合物涉及DNA结合蛋白抑制剂3(ID3)基因和对应于SEQ ID NO:2位置2702的骨形态发生蛋白4(BMP4)基因中的SNP。通过测量TGF-信号通路中一种或多种靶基因的表达水平并仅选择靶基因表达水平未上调的胚胎进行植入来确定牛胚胎发育能力的方法。
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