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CHIMERIC ANTIGEN RECEPTORS AND IMMUNE CELLS TARGETING B CELL MALIGNANCIES
CHIMERIC ANTIGEN RECEPTORS AND IMMUNE CELLS TARGETING B CELL MALIGNANCIES
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机译:嵌合抗原受体和免疫细胞针对B细胞恶性肿瘤
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摘要
The disclosure describes genetically engineered CD37 specific redirected immune effector cells expressing a chimeric antigen receptor (CAR) protein comprising an antigen binding domain derived from an antibody, a single chain antibody or portion thereof that binds CD37; a hinge region; a transmembrane domain and an intracellular signaling domain derived from human CD3ζ or FcRγ; and optionally one or more co-stimulatory intracellular signaling domains The invention includes nucleic acids, vectors and immune effector cells associated with the production of the CAR protein, as well as methods of treating B cell malignancies in humans by cellular immunotherapy.
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