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Treatment of neurological diseases using adeno-associated virus (AAV) comprising AAV-5 capsid proteins
Treatment of neurological diseases using adeno-associated virus (AAV) comprising AAV-5 capsid proteins
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机译:使用包含AAV-5衣壳蛋白的腺相关病毒(AAV)治疗神经系统疾病
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摘要
The present invention relates to methods for treating disorders affecting motor function, such as motor function affected by disease, injury to the brain and/or spinal cord using an adeno-associated virus (AAV) gene therapy vector comprising adeno-associated virus 5 (AAV5) capsid proteins and a gene product of interest flanked by AAV ITRs. In particular, the gene therapy vector of the present invention is administered via injection into the cerebrospinal fluid (CSF), preferably by lumbar injection and/or injection into the cisterna magna.
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