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Pharmaceutical Composition for Elevating Radiation-Sensitivity of Cancer Cells, Pharmaceutical Composition for Detecting Cancer Cells with Radiation-Sensitivity, and Detection Method Thereof
Pharmaceutical Composition for Elevating Radiation-Sensitivity of Cancer Cells, Pharmaceutical Composition for Detecting Cancer Cells with Radiation-Sensitivity, and Detection Method Thereof
The present invention relates to a pharmaceutical composition for elevating radiation-sensitivity of cancer cells, which comprises: a nanoparticle containing with a first element, which is iron, copper, or the combination thereof; and a pharmaceutically acceptable carrier, wherein the nanoparticle is a metal nanoparticle, an alloy nanoparticle, or a metal nanoparticle with core-shell structure. In addition, the present invention provides a detection method to detect radiation-sensitivity of the cancer cells through different modalities such as CT or MRI due to its native high CT number and magnetic property. Furthermore, the present invention provides a pharmaceutical composition for elevating radiation-sensitivity of the cancer cells through preferential uptake of the nanoparticle, in order to enhance the radiation-sensitivity of the cancer cells and improve the efficiency of radiation therapy to the cancer cells.
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