Anti-demodectic active agents and topical compositions for the treatment of demodicosis in humans and animals

摘要

The present invention is directed to topical compositions and methods for preventing and treating demodicosis and the symptoms of demodectic mites, including blepharitis, meibomian gland dysfunction, type 1 flushing rosacea, type 2 acne rosacea, type 4 ocular rosacea, demodicosis gravis, granulomatous rosacea, and pityriasis folliculorum, by topical administration of a therapeutically effective amount of piroctone olamine, and in some embodiments, climbazole.