DEREPRESSION OF IMMUNITY IN ONCOLOGICAL AND VIROLOGICAL CONDITIONS BY HIGH MOBILITY GROUP BOX 1 DERIVED PEPTIDES

摘要

Disclosed are compositions of peptides derived from the High Mobility Group Box 1 (HMGB1) protein that are useful in suppressing inhibitory activity of T regulatory cells in conditions of cancer and virus infections. Specifically, this application provides means of derepressing immunity in a state of immune suppression through significantly decreasing the number and/or activity of T regulatory cells.