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SMALL INTERFERENCE RNAS, USES THEREOF AND METHOD FOR INHIBITING THE EXPRESSION OF PLK1 GENE
SMALL INTERFERENCE RNAS, USES THEREOF AND METHOD FOR INHIBITING THE EXPRESSION OF PLK1 GENE
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机译:小干扰RNA,其用途和抑制PLK1基因表达的方法
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摘要
The present invention provides siRNAs for inhibiting the expression of plk1 gene, and the method for inhibiting the expression of plk1 gene in mammalian cells. The siRNAs of the present invention have the double-stranded structure, and said double-stranded structure is composed of the first single strand and the second single strand that are fully complementary, wherein the sequence of said first single strand is the same as the target sequence within the sequence as shown in SEQ ID NO: 1, and the sequence of said second single strand is complementary to the target sequence within the sequence as shown in SEQ ID NO: 1. The siRNAs of the present invention can sequence specifically mediate the inhibition of plk1 gene expression, and have a good serum stability. By the introduction of the siRNAs of the present invention into the tumor cells, the expression of plk1 gene can be effectively inhibited, and the growth of tumor cells is inhibited and the apoptosis of tumor cells is promoted.
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机译:本发明提供了在哺乳动物细胞中抑制plk1基因表达的siRNA和抑制plk1基因表达的方法。本发明的siRNA具有双链结构,并且所述双链结构由完全互补的第一单链和第二单链组成,其中所述第一单链的序列与靶标相同。所述第二单链的序列与SEQ ID NO:1所示的序列中的靶序列互补。所述第二单链的序列与SEQ ID NO:1所示的序列中的靶序列互补。抑制plk1基因表达,并具有良好的血清稳定性。通过将本发明的siRNA导入肿瘤细胞,可以有效地抑制plk1基因的表达,并且抑制肿瘤细胞的生长,促进肿瘤细胞的凋亡。
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