首页>
外国专利>
Recombinant rift valley fever (RVF) viruses and methods
Recombinant rift valley fever (RVF) viruses and methods
展开▼
机译:裂谷热(RVF)重组病毒和方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.
展开▼