首页> 外国专利> DITERPENOID MEMBRANOLIDE COMPOUNDS HAVING ANTI-LEISHMANIA ACTIVITY AND USES THEREOF

DITERPENOID MEMBRANOLIDE COMPOUNDS HAVING ANTI-LEISHMANIA ACTIVITY AND USES THEREOF

机译：具有抗利什曼原虫活性的双萜类膜化物及其用途

页面导航

摘要
著录项
相似文献

摘要

In a screening program, the Antarctic sponge Dendrilla membranosa was found to produce diterpenoid secondary metabolites with activity against the leishmaniasis-causing parasite Leishmania donovani. The present invention concerns compositions useful for control of Leishmania spp. parasites in vitro and in vivo and treatment of leishmaniasis; methods for treatment of leishmaniasis; and methods for controlling Leishmania spp. parasites in vitro and in vivo.

机译：在一个筛选程序中，发现南极海绵 Dendrilla membranosa 会产生二萜类次生代谢产物，其具有抗利什曼病的寄生虫 Leishmania donovani 的活性。本发明涉及可用于控制利什曼原虫 spp的组合物。体外和体内寄生虫和利什曼病的治疗;治疗利什曼病的方法;和控制利什曼原虫 spp的方法。体内和体外寄生虫。 展开▼

著录项

公开/公告号US2016030388A1

专利类型

公开/公告日2016-02-04

原文格式PDF

申请/专利权人 BILL J. BAKER;CHRISTOPHER G. WITOWSKI;JOHN ALAN MASCHEK;BRIAN VESELY;DENNIS E. KYLE;
展开▼

申请/专利号US201514811341

发明设计人 BILL J. BAKER;CHRISTOPHER G. WITOWSKI;JOHN ALAN MASCHEK;BRIAN VESELY;DENNIS E. KYLE;
展开▼

申请日2015-07-28

分类号A61K31/365;A61K45/06;A61K31/343;A61K31/366;

国家 US

入库时间 2022-08-21 14:33:21

相似文献

专利

外文文献

中文文献

1. 烟草中一种具有抗烟草花叶病毒活性的倍半萜类化合物、其制备方法和用途 [P] . 中国专利： CN105175239B . 2017.03.22

2. 烟草中一种具有抗烟草花叶病毒活性的倍半萜类化合物、其制备方法和用途 [P] . 中国专利： CN105175239A . 2015-12-23

3. Diterpenoid membranolide compounds having anti-leishmania activity and uses thereof [P] . 美国专利： US9872849B2 . 2018-01-23

机译：具有抗利什曼原虫活性的二萜类膜状化合物及其用途

4. Novel abietane diterpenoid compound and sputum extract, or composition for prevention and treatment of cardiovascular disease comprising as an active ingredient an abietane diterpenoid compound or terpenoid compound isolated therefrom [P] . 日本专利： JP4777970B2 . 2011-09-21

机译：新颖的枞果二萜化合物和痰提取物，或用于预防和治疗心血管疾病的组合物，其包含从其中分离的枞果二萜化合物或萜类化合物作为活性成分

5. Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease [P] . 美国专利： US7825162B2 . 2010-11-02

机译：松果双萜化合物，以及包含其的提取物的组合物，或从松香中分离出的松果双萜化合物或萜类化合物用于预防和治疗心血管疾病

1. Antioxidant, lipid peroxidation inhibition and free radical scavenging efficacy of a diterpenoid compound sugiol isolated from Metasequoia glyptostroboides [J] . Vivek K Bajpai, Ajay Sharma, Sun Chul Kang, 亚太热带医药杂志（英文版） . 2014,第001期

2. In Vitro Anti-Proliferative Activity of Curcuma Angustifolia and Estimation of Bioactive Compounds for Antioxidant Activity [J] . Shiwoto, Ruth, Assumi, 食品科学与工程：英文版 . 2017,第001期

3. In vitro activity of natural honey alone and in combination with curcuma starch against Rhodotorula mucilaginosa in correlation with bioactive compounds and diastase activity [J] . Moussa Ahmed, Noureddine Djebli, Saad Aissat, 亚太热带生物医学杂志（英文版） . 2013,第010期

4. In vitro activity of natural honey alone and in combination with curcuma starch against Rhodotorula mucilaginosa in correlation with bioactive compounds and diastase activity [J] . Moussa Ahmed, Noureddine Djebli, Saad Aissat, 亚太热带生物医学杂志：英文版 . 2013,第010期

5. In vitro anti-Leishmania activity of T6 synthetic compound encapsulated in yeast-derived beta-(1,3)-D-glucan particles [J] . Volpato Helito, Scariot Debora Botura, Pais Soares Edna Filipa, International Journal of Biological Macromolecules: Structure, Function and Interactions . 2018,第期

6. Hybrid Compounds of ent-Beyerane Diterpenoid Isosteviol with Pyridinecarboxylic Acid Hydrazides. Synthesis, Structure,and Antitubercular Activity [J] . O. V. Andreeva, R. R. Sharipova, I. Yu. Strobykina Russian Journal of General Chemistry . 2011,第8期

7. ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway. [J] . Deng R, Tang J, Xia LP, Molecular cancer therapeutics . 2009,第4期

8. Bioactive metabolites from the Andean flora. Antituberculosis activity of natural and semisynthetic azorellane and mulinane diterpenoids [C] . Gloria Maria Molina-Salinas, Jorge Borquez, Alejandro Ardiles Phytochemistry Reviews: Fundamentals and Perspectives of Natural Products Research . 2010

9. Identification of a Novel Compound with MITF Suppression Activity and Apoptosis Induction Activity in Combination with BRAF Inhibitors [D] . 相田智志 2019

10. Cytotoxicity and anti-Leishmania amazonensis activity of Citrus sinensis leaf extracts [O] . Andreza R. Garcia, Ana Claudia F. Amaral, Mariana M. B. Azevedo, 2017

11. Recent Advances in the Chasing for Organic Compounds with Potential Anti-Leishmania Activity [O] . Ana C. Micheletti, Adilson Beatriz 2012

1. Cembrane-Type Diterpenoids and a Phenolic Compound from the Leaves of a Thai Medicinal Plant, iCroton sublyratus/iKurz [J] . Yasue Oka ,Susumu Kawakami ,Sachiko Sugimoto . 美国植物学期刊（英文） . 2014,第9期

2. 卷柏中具有抗白血病细胞增殖活性的新甾醇类化合物 [C] . 高亮亮 ,李占林 ,殷世亮 . 第九届全国中药和天然药物学术研讨会 . 2007

3. 同时多原发性非小细胞肺癌临床特征与外科治疗疗效分析；PH17是新的具有抗肿瘤活性的香茶菜属二萜类化合物 [A] . 章智荣 . 2016