Method of inducing cellular differentiation using the Notch3 receptor intracellular domain

摘要

The present invention relates to the intracellular domain of Notch3 that can activate signaling and initiate transcription, thereby initiating cellular differentiation in general, and neuronal differentiation in particular. The present invention includes the use of polynucleotide sequences that code, entirely or partially, for the intracellular domain of Notch3, for the purpose of inducing cellular differentiation. The present invention includes the use of Notch3 intracellular domain polynucleotide or polypeptide sequences for the purpose of treating diseases or disorders, by inducing cellular differentiation.