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SCREENING ASSAY FOR IDENTIFICATION OF POLY(ADP-RIBOSE) POLYMERASE 1 INHIBITORS
SCREENING ASSAY FOR IDENTIFICATION OF POLY(ADP-RIBOSE) POLYMERASE 1 INHIBITORS
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机译:鉴定多聚(ADP-核糖)聚合酶1抑制剂的筛选试验
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摘要
Screening methods as well as systems and kits for identifying inhibitors of DNA-independent, histone H4-dependent activation of PARP-1 are provided. The methods comprise screening molecules for their capacity to inhibit the activation and/or biologic activity of PARP-1, as measured by poly(ADP)-ribose production from nicotinamide adenine dinucleotide. PARP-1 inhibitors identified through the screening methods may be used to treat cancer in which PARP-1 activation or biologic activity plays a role.
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