Fiber optic analyte sensor with integrated in situ total pressure correction

摘要

A fiber optic analyte sensing needle employing an analyte-partial-pressure-sensitive photoluminescent probe, characterized by (i) a void volume channel extending axially along the length of the lumen between the inner surface of the tube and the outer surface of the fiber optic filament, and (ii) a total pressure sensor in pressure communication with the distal tip of the needle via the void volume channel, whereby total pressure of a volume sampled by the sensing needle can be routinely measured and used in pressure compensation of analyte-concentration values calculated from the analyte-partial-pressure readings taken from the analyte-partial-pressure-sensitive photoluminescent probe.