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Methods for producing methionine by culturing a microorganism modified to enhance production of cysteine

机译:通过培养经修饰以增强半胱氨酸生产的微生物来生产蛋氨酸的方法

摘要

A method of producing methionine, derivatives or precursors thereof includes culturing a modified microorganism in a culture medium comprising a source of carbon and a source of sulfur; and recovering methionine from the culture medium, wherein said modified microorganism has an increased expression of cysE gene encoding serine acetyltransferase, metH gene encoding methionine synthase and metF gene encoding 5,10-methylenetetrahydrofolate reductase compared to expression of the cysE, metH and metF genes in an unmodified microorganism.
机译:一种生产蛋氨酸,其衍生物或前体的方法,包括在含有碳源和硫源的培养基中培养修饰的微生物。和从培养基中回收蛋氨酸,其中所述修饰的微生物与cysE,metH和metF基因的表达相比,具有增加的编码丝氨酸乙酰基转移酶的cysE基因,编码蛋氨酸合酶的metH基因和编码5,10-亚甲基四氢叶酸还原酶的metF基因的表达。未经修饰的微生物。

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