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Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

机译：具有选择性抗疟疾活性的二氢乳清酸脱氢酶抑制剂

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摘要

Compounds according to Formula I, Formula II, Formula III, Formula V, Formula VI, or to Formula VII,; embedded image

and pharmaceutical compositions of compounds that conform to Formula IV or Formula VIII:; embedded image

where R¹through R³³are prescribed, selectively inhibit P. falciparum dihydroorotate dehydrogenase. Accordingly, a method for preventing and treating malaria attaches to such compounds, as well as to pharmaceutically acceptable salts, solvates, stereoisomers, tautomers, and prodrugs thereof.

机译：根据式I，式II，式III，式V，式VI或式VII的化合物; “嵌入式图像”

和符合式IV或式VIII的化合物的药物组合物：; “嵌入式图像”

其中规定了R ^{1 至R ^{33 ，选择性抑制 P。恶性疟原虫二氢乳清酸脱氢酶。因此，预防和治疗疟疾的方法附着于此类化合物及其药学上可接受的盐，溶剂化物，立体异构体，互变异构体和前药。}} 展开▼

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公开/公告号US9216983B2

专利类型

公开/公告日2015-12-22

原文格式PDF

申请/专利权人 MARGARET PHILLIPS;PRADIPSINH K. RATHOD;RAMESH GUJJAR;ALKA MARWAHA;SUSAN A. CHARMAN;
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申请/专利号US20080339905

发明设计人 MARGARET PHILLIPS;PRADIPSINH K. RATHOD;RAMESH GUJJAR;ALKA MARWAHA;SUSAN A. CHARMAN;
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申请日2008-12-19

分类号C07D487/04;C07D473/34;A61K31/519;

国家 US

入库时间 2022-08-21 14:29:48

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