A computer-implemented method for predicting the impact of security-policy changes on users may include (1) identifying at least one end-user computing system that may potentially be regulated using a security policy, (2) predicting, prior to activating the security policy on the end-user computing system, how activating the security policy may impact at least one user of the end-user computing system by monitoring at least one behavior of the user on the end-user computing system and by determining how activating the security policy on the end-user computing system may have impacted the behavior, and (3) notifying, based at least in part on predicting how activating the security policy may impact the user, an administrator of the end-user computing system with information that indicates how activating the security policy may impact future user behavior. Various other methods, systems, and computer-readable media are also disclosed.
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