Methods and compositions related to Staufen 1 binding sites formed by duplexing Alu elements

摘要

Disclosed are compositions and methods for identifying binding sites of targets of Stau1-mediated mRNA decay; methods and compositions for treating subjects with conditions resulting from Stau1-mediated mRNA decay, and method of screening for therapeutic agents. Also disclosed is the new pathway as a means for cells to down-regulate the expression of Stau1-binding mRNAs.