It is composed of a peptide receptor similar to the first type of glucose (GLP-1) and a hypnotic agent similar to the glucose based insulin cholesterol (GIP) receptor

摘要

The present invention provides a peptide compound that exerts an activating action on GLP-1 receptors and GIP receptors, as well as the use of the peptide compound as a medicine intended for the prophylaxis or treatment of obesity or diabetes. Claim 1: A peptide characterized in that it comprises a partial sequence represented by the formula (1): P¹-Tyr-Aib-Glu-Gly-Thr-aMePhe-Thr-Ser-Asp-Tyr-A¹¹-A¹²-A¹³-Leu-Asp -A¹⁶-A¹⁷-Ala-Gln-A²⁰-Glu-Phe-Val-Lys-Trp-Leu-Leu-Lys-A²⁹ (1) where P¹ is a group represented by the formula: -RA¹,-CO-RA1,-Pray together 1,-Co-kola 1,-So-Ra1,-SO₂-RA¹,-SO₂-ORA¹,-Union-nra-3,-So-832222-nra 3 O-C (= nra1) - NRA 3, where ra1,2. Ra2 and RA'm are a hydrogen atom, an alternative hydrocarbon group or an alternative heterocycle group respectively; A1 is AIB or ala; A2 is ala, ile, Lys, Phe or PYA (4);A1 3 is AIB, Cha, Leu, amefe or ametyr; A1 8310 is Lys or ser; A1 18311 is Gln or ile; A2 83044 is wing or ser; A2 83313 is Gln or Gly; or sa