II. Preparation and use of office design methods

摘要

1. Claim 1: one comprising: (a) combining the molecular fluorescence rotor compound with the mineral oil as the recovery agent to obtain the first mixture; (b) stirring the former mixture with the ball grinding and grinding method; A second mixture is obtained in this way; and (c) a second mixture is mixed with an underwater listening vehicle to obtain a grapefruit. 6. Characteristic 6: characteristic 5 process, the grinding medium is zirconium, and solidified with nitric acid. Requirement 12: procedure for any of the above requirements,Molecular fluorescence rotor compounds have structural formula (1),or one of its pharmaceutically acceptable salts, in which: A¹ is an optionally substituted C₆₋₁₈ arylene, an optionally substituted C₅₋₁₈ heteroarylene, or is represented by structural formula (2);R¹ and R² are each independently hydrogen, optionally substituted C₁₋₁₂ alkyl, an optionally substituted C₁₋₁₂ heteroalkyl, optionally substituted C₃₋₁₂ cycloalkyl, or R¹ and R² taken together with the nitrogen atom to which they are attached form a heterocycloalkyl of 3 to 12 members optionally substituted; R³ and R⁴ are each independently hydrogen, methyl, or ethyl; R⁵ is -OH, -O (C₁₋₆ alkyl) optionally substituted, -NR⁶R⁷ or is represented by structural formula (3);R8310a and r8311a are independent. Hydrogen, methyl, ethyl or r8310a and r8311a together with the nitrogen atoms attached to them form a 5 to 7 heterocyclic compounds, including 1 to 3 heteroatoms, which are independently selected from n, O and s respectively; the integer is 1 to 10; r831222;Each time it appears independently, it is hydrogen - Oh, o-ch8322;; Oh, r8313 is hydrogen - nr.8304;; R1,-C (O) Roptionally substituted C₁₋₆ alkyl, optionally substituted C₁₋₆ heteroalkyl; R¹⁰,R¹¹ and R¹² are each independently hydrogen or C₁₋₆ alkyl.