Antibody (disintegrin and metalloproteinase ADAM17 (- 17) and their use for the treatment of cancer

摘要

This refers to an Antibody capable of binding to ADAM17, and moreover, the amino acid and Nucleic Acid sequences encoding Said Antibody. In One aspect, relates to an Antibody or Antigen binding Fragments capable of binding to ADAM17 with Antitumor Activity. Also includes the use of this Antibody as a drug for the treatment of cancer.Finally, includes compositions comprising Said Antibody, alone or in combination with other compounds or Conjugation against cancer, and use these for the treatment of cancer.Claim 1: a monoclonal antibody or its Fragments of Union of Antigen Epitope, which binds even ADAM17 and Inhibits the diffusion of at least a substrate of ADAM17, wherein Said epitope of ADAM17 is an epitope within the next domain Mo Membrane (PDM) sequence of the sec. ID no. 32.