Use of a compound of 15 Keto prostaglandin for the manufacture of a composition for treating Drug induced constipation

摘要

Use of a compound 15 Keto prostaglandin for the manufacture of a Pharmaceutical composition for treating constipation induced by drugs, where the 15 Keto prostaglandin Compound represented by the General formula (1), where l, M and N are Hydrogen, halogen, alkyl, hydroxyl, INF Higher (or lower), hidroxialquilo oxoWhere at least one of L and M is a different Group of hydrogen, and the five membered Ring may have at least one double Bond; it is chu2082oh cochu2082oh -, -, - Coon or a functional derivative thereof; b is chu2082 - chu2082 -, - ch = CH - or - cu00bac; ru00b9 is a residue or aliphatic Hydrocarbon Bivalent less saturated or unsaturated is replaced or not replaced with Halogen, alkyl, hydroxyl,Oxo, aryl or Heterocyclic Group and at least one carbon Atom in the aliphatic Hydrocarbon is optionally substituted by Oxygen, nitrogen or Sulfur; and ru1d43 is a residue of Middle or lower aliphatic Hydrocarbon saturated or unsaturated, is replaced or not replaced with halu00f3g Eno, Oxo, hydroxyl, alkoxyl alcanoiloxilo Lower, Lower, cycloalkyl (bottom)Cicloalquiloxilo (bottom), aryl or Heterocyclic Group, ariloxilo, - oxilo Heterocyclic Group. The composition obtained has a strong antagonistic Action against the drug induced constipation without losing substantially the main effect of the drug.