Complex poliproteu00cdnas inmunogu00c9nicas M. hyopneumoniae, Synthetic gene encoding Complex proliproteu00cdnas inmunogu00c9nicas M. hyopneumoniae antigu00c9nica, composition, Process for obtaining a complex poliproteu00cdnas inmunogu00c9nicas M. hyopneumoniae, use of a composition Based on the complex poliproteu00cdnas inmunogu00c9nicas M. hyopneumoniae

摘要

This refers to a complex of polyproteins containing immunogenic regions derived antigens P36, P46, HSP, NRDF, p97, and mhp271 p216 M. hyopneumoniae, these regions are merged with segments of the rrp4 rrp41 Carrier Proteins, and rrp42 p. abyssi, form When a single Complex.Other additional Objects of this provide: (i) a gene encoding the polyprotein Complex, based on the exosome complex of p. abyssi Vaccine Antigen carrying copies of M.Hyopneumoniae; (ii) an antigenic composition comprising the complex of polyproteins of the present, optionally one or more Additives and / or additional vehicle and a pharmacologically acceptable; (iii) a process for obtaining Said polyprotein Complex; and (iv) uses the Comp The distance and the composition in the treatment and Prevention of infections caused by M. hyopneumoniae.Claim 3: M polyprotein Complex immunogen.Understand hyopneumoniae, characterized by a sequence of amino acids selected from: (a) SEQ ID no. 26, SEQ ID no. 27 and SEQ ID no. 28; (b) variants modified conservatively with at least 85% identity in the amino acid sequences of the sequences SEQ ID no. 2 6, SEQ ID no. 27 and SEQ ID no. 28And with substantially the same immunogenic activity of these Fragments; (c) the sequence of SEQ ID no. 26, SEQ ID no. 27 and SEQ ID no. 28, these Fragments including immunogenic antigens and stable regions of P36, P46, HSP (P42), NRDF, p97, and mhp271 p216; and (d) a pro Fusion Protein encoded by the Nucleotide sequence of SEQ ID no. 25A modified variant of the conservatively fusion protein or a fragment of the fusion protein with the same immunogenic activity.