neurturin polypeptide, method of treating cell degeneration or insufficiency, pharmaceutical composition, isolated polynucleotide conducting a recombinant vector polypeptide, host cell, and pharmaceutical delivery system.

摘要

Neurturin polypeptides which possess reduced heparin and heparan sulfate binding affinity but retain neurotrophic activity, nucleic acids which encode the neurturin variants and vectors and host cells which express the enhanced neurturin polypeptides. Use of the enhanced neurturin polypeptides, nucleic acids and host cells in the treatment or prevention of disease.