antibody, antibody functional fragment, pharmaceutical composition, uses of an antibody or functional fragment thereof and at least one member selected from the group consisting of paclitaxel, carvoplatin, cpt-11, vinblastine, and 5-fu, polynucleotide, vector , transformed host cell, and method of producing antibody

摘要

antibody, antibody functional fragment, pharmaceutical composition, uses of an antibody or functional fragment thereof and at least one member selected from the group consisting of paclitaxel, carvoplatin, cpt-11, vinblastine, and 5-fu, polynucleotide, vector , transformed host cell, and method of producing the antibody. The present invention relates to an antibody that has a therapeutic effect on cancer, autoimmune diseases, or inflammatory diseases. that is, the present invention relates to an antibody that exhibits apoptosis-mediated cytotoxic activity on a cell expressing a death domain-containing receptor. The present invention addresses the problem of providing a medicament that has a therapeutic effect on cancer. The present invention clarifies that a novel anti-dr5 antibody, which is capable of inducing apoptosis in a cell, has marked cytotoxic activity compared to conventional anti-dr5 antibodies.