Process for the operation of a distillation column for the removal of water and components with boiling point lower than that of 1,2-dichloroethane

摘要

Process for the operation of a distillation column for the purification of 1,2-dichloroethane and the concentration coupled to caustic soda solution by evaporation.The present invention relates to a process for the operation of a distillation column for the removal of water and components having a boiling point lower than 1, 2 - dichloroethane of 1, 2 - dichloroethane in which at least part of the heat of condensation of the vapors of the column of aqueous Stilau00e7u00e3o is used to concentrate the caustic soda solution through evaporation; in addition,At least part of 1, 2 - dichloroethane formed when chlorine and ethylene react in a direct chlorination unit is used to heat the distillation column and can subsequently be used as a heat transfer fluid to concentrate the solution of caustic soda Through evaporation.A ring heterociclico non aromatic, non substituted or substituted or one or two substituents selected from the group, which consists of (C (0) 0 - lower alkyl, lower alkyl, lower alkyl substituted by halogen, CI loalquila, hidru00f4xi, halogen, n (R) (C (0) - lower alkyl, - Ch ~ 2 ~) ~ n ~ - aiquiia below, or by a heterociclico aromatic ring; R is hydrogen, hydroxy,Or lower alkyl, R may be the same or different in the case of R ^ 2 ^; "/ R" are independently hydrogen or lower alkyl; a is, 1,2,3ou4; m him, 2ou3; and their pharmacologically acceptable acid addition salts.It was found that this class of compounds shows high affinity and selectivity with respect to the places of connection of GABA receptor 244 5 and could be useful as cognitive enhancer or for the treatment of dis - tu00farbios cognitive and Alzheimer's disease.