interferon alfa 2a modified by polyethylene glycol, the preparation and use thereof.

摘要

The present invention relates to interferon (IFN)-±2a modified at a specific Lys residue with Y-shaped branched polyethylene glycol (PEG) derivative and the preparation thereof, as well as the use of the prepared IFN-±2a modified by PEG at a single amino acid residue in medicines.