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Method for the production of a solution containing high molecular weight isolated streptococcus pneumniae capsular polysaccharides, as well as a solution containing said polysaccharides
Method for the production of a solution containing high molecular weight isolated streptococcus pneumniae capsular polysaccharides, as well as a solution containing said polysaccharides
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机译:包含高分子量分离的肺炎链球菌荚膜多糖的溶液的制备方法,以及包含所述多糖的溶液的制备方法
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摘要
The present invention provides improved methods for producing a solution containing high molecular weight isolated Streptococcus pneumoniae capsular polysaccharides having phosphodiester linkages between saccharide repeat units. In certain methods, CO2 is supplied to a fermentation culture of Streptococcus pneumoniae bacterial cells that produce capsular polysaccharide serotypes containing phosphodiester linkages between saccharide repeat units. Exemplary Streptococcus pneumoniae serotypes containing a phosphodiester linkage between saccharide repeat units include serotypes 6A, 6B, 19A, and 19F. Supplying CO2 to the fermentation culture includes adding bicarbonate ions to the fermentation culture, adding carbonate ions to the fermentation culture, adding mixtures of bicarbonate and carbonate ions to the fermentation culture, and overlaying the fermentation culture with CO2.
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