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mir-208 and mir-499 dual targeting in the treatment of heart disease.
mir-208 and mir-499 dual targeting in the treatment of heart disease.
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机译:mir-208和mir-499双重靶向治疗心脏病。
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摘要
The present invention provides a method of treating or preventing cardiac disorders in a subject in need thereof by inhibiting the expression or function of both miR-499 and miR-208 in the heart cells of the subject. In particular, specific protocols for administering inhibitors of the two miRNAs that achieve efficient, long-term suppression are disclosed. In addition, the invention provides a method for treating or preventing musculoskeletal disorders in a subject in need thereof by increasing the expression or activity of both miR-208 and miR-499 in skeletal muscle cells of the subject.
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