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opioid dicarboxylic acid-linked amino acid and peptide prodrugs and their uses
opioid dicarboxylic acid-linked amino acid and peptide prodrugs and their uses
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机译:阿片类二羧酸连接的氨基酸和肽前药及其用途
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摘要
The present invention concerns dicarboxylic acid linked amino acid and peptide prodrugs of opioid analgesics and pharmaceutical compositions containing such prodrugs. Methods for providing pain relief, decreasing the adverse GI side effects of the opioid analgesic and increasing the bioavailability of the opioid analgesic with the aforementioned prodrugs are also provided. In one embodiment, prodrugs having the amino acid side chains of valine, leucine, isoleucine and glycine; and mono-, di- and tripeptides thereof are provided.
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