Acylhydrazones as prototype of new drugs for acute lymphoid leukemia (lla)

摘要

Acyl Hydrazones as a Prototype of Novel Acute Lymphoid Leukemia Drugs (ILA) The present invention relates to a class of acylhydrazones, especially those derived from 3,4,5-trimethoxyphenylhydrazide, as well as their oxadiazole analogues and other similar compounds, and pharmaceutical application of all these compounds in the treatment of different cell proliferation-associated diseases, such as leukemias, including acute lymphoid leukemia (lla), tumors, and inflammation. This invention also describes the processes used for determining the biological activity of all these compounds. acylhydrazones with activity similar to the compound used as standard in the experiments (colchicine) were obtained. The higher selectivity of the compounds presented in this invention is an important feature related to lower side effects than the drugs currently employed in the clinic. Synthesized acylhydrazones, specifically compounds 02 and 07, showed important antileukemic activity, indicating 02 and 07 as candidates for prototype drugs, or drugs, for the treatment of leukemias, especially acute lymphoid leukemia (lla), tumors. and other proliferative diseases such as inflammation. The determination of the mechanism of action of the most active compounds was performed by the use of DNA microarrays and subsequent tests indicated through the chip, as well as selectivity studies in healthy human lymphocytes.